Bleeding risks for uncharacterized platelet function disorders
نویسندگان
چکیده
منابع مشابه
Peri-operative platelet function testing: the potential for reducing ischaemic and bleeding risks.
The pivotal role of platelet activation and reactivity during atherothrombotic event occurrence associated with acute coronary syndromes (ACS) or percutaneous coronary interventions (PCI) is well established. Numerous translational research studies have established a threshold level of platelet reactivity during dual antiplatelet therapy above which a higher risk for ischaemic event occurrence ...
متن کاملPlatelet function disorders.
Platelet function defects comprise a large and heterogeneous group of bleeding disorders that range in severity from mild to severe. Patients may be asymptomatic; however, the majority who are diagnosed present with easy bruising and mucocutaneous bleeding, or with excessive haemorrhage following injury or surgery. As the complex internal biochemical and signal transduction pathways are further...
متن کاملDisorders of platelet function.
Careful study of the hereditary defects of platelet function, like that of the congenital coagulation disorders, has made a large contribution to our understanding of the normal haemostatic mechanism. I should like today to discuss the evolution of knowledge about this uncommon group of disorders to indicate how they help to advance our understanding of normal platelet physiology, and to point ...
متن کاملCurrent status and future prospects for platelet function testing in the diagnosis of inherited bleeding disorders.
Platelets play a crucial role in haemostasis by preventing bleeding at the site of vascular injury. Several defects in platelet morphology and function have been identified and described over the years. Although a range of methodologies is available to assess platelet function, a significant proportion of subjects with bleeding symptoms and normal coagulation parameters still appear to have nor...
متن کاملAcquired disorders of platelet function.
Platelet dysfunction is commonly acquired due to medications, procedures, medical conditions, and underlying hematologic disease. These issues are presented, the data reviewed, and recommendations given herein. Many medications and dietary supplements have platelet-inhibitory effects in vitro, although the clinical effects on bleeding risks are unclear for many. Platelet-inhibitory drugs are ke...
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ژورنال
عنوان ژورنال: Research and Practice in Thrombosis and Haemostasis
سال: 2020
ISSN: 2475-0379,2475-0379
DOI: 10.1002/rth2.12374